Treatment of Add Treatment for Add typically involves psychosocial and medication. how to treat adhd can include stimulants like methylphenidate or amphetamines, in addition to nonstimulants such as bupropion (Wellbutrin) and atomoxetine, as well as tricyclic antidepressants. For comorbid mood instability, mood-stabilizing drugs like clonidine (Catapres) and guanfacine(Kappvay) can